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Lyophilized DSIP as Growth Hormone Peptides Delta Sleep-Inducing Peptide for bodybuilding

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Lyophilized DSIP as Growth Hormone Peptides Delta Sleep-Inducing Peptide for bodybuilding

Brand Name : Biopro
Model Number : PEP-124
Certification : GMP/HACCP/ISO
Place of Origin : China
MOQ : 1 box
Price : USD1~100/Box
Payment Terms : T/T, Western Union, MoneyGram
Supply Ability : 1000 boxes per week
Delivery Time : Immediate Shipping
Packaging Details : 10 vials/box
Product Name : DSIP
Other Name : Delta Sleep-Inducing Peptide
Molecular Formula : C35H48N10O15
Package : 2 mg/vial
Product Type : Lyophillized Powder
Color : White
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Lyophilized DSIP as Growth Hormone Peptides Delta Sleep-Inducing Peptide for bodybuilding


  • Description

    Delta sleep-inducing peptide, abbreviated DSIP, is a neuropeptide that when infused into the mesodiencephalic ventricle of recipient rabbits induces spindle and delta EEG activity and reduced motor activities.

    Its amino acid sequence is Тrр-Аlа-Gly-Gly-Asp-Ala-Ser-Gly-Glu. However, the gene is unknown [citation needed], raising serious questions regarding the actual existence of this peptide in nature.

  • Specification

    Name: DSIP
    Synonyms: Delta Sleep-Inducing Peptide
    CAS No.: 62568-57-4
    Molecular Formula: C35H48N10O15
    Molecular Mass: 848.34 Da (g/mol)
    Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
    Structure:



  • Purity
    DSIP has a peptide purity level that exceeds 99.0% as determined by HPLC.

  • Application Information

    Delta sleep-inducing peptide was first discovered in 1974 by the Swiss Schoenenberger-Monnier group who isolated it from the cerebral venous blood of rabbits in an induced state of sleep. It was primarily believed to be involved in sleep regulation due to its apparent ability to induce slow-wave sleep in rabbits, but studies on the subject have been contradictory.

    Many roles for DSIP have been suggested following research carried out using peptide analogues with a greater molecular stability and through measuring DSIP-like immunological (DSIP-LI) response by injecting DSIP antiserum and antibodies.

    Roles in endocrine regulation
    > Decreases basal corticotropin level and blocks its release.
    > Stimulates release of luteinizing hormone (LH).
    > Stimulates release of somatoliberin and somatotrophin secretion and inhibits somatostatin secretion

    Roles in physiological processes
    > Can act as a stress limiting factor
    > May have a direct or indirect effect on body temperature and alleviating hypothermia
    > Can normalize blood pressure and myocardial contraction.
    > It has been shown to enhance the efficiency of oxidative phosphorylation in rat mitochondria in vitro, suggesting it may have antioxidant effects.
    > There is also conflicting evidence as to its involvement in sleep patterns. Some studies suggest a link between DSIP and slow-wave sleep (SWS) promotion and suppression of paradoxical sleep, (PS) while some studies show no correlation. Stronger effects on sleep have been noted for the synthesized analogues of DSIP.
    > It may have an impact on human lens epithelial cell function via the MAPK pathway, which is involved in cell proliferation, differentiation, motility, survival, and apoptosis.

    Roles in disease and medicine
    > It has been found to have anticarcinogenic properties. In a study on mice, injecting a preparation of DSIP over the mice's lifetime decreased total spontaneous tumor incidence 2.6-fold.
    > The same study found it to also have geroprotective effects: it slowed down the age-related switching-off of oestrous function; it decreased by 22.6% the frequency of chromosome aberrations in bone marrow cells and it increased by 24.1% maximum life span in comparison with the control group.
    > Levels of DSIP may be significant in patients diagnosed with major depressive disorder (MDD). In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients.
    > Studies have demonstrated a direct link between GILZ expression (homologous to DSIP) and adipogenesis which has links to obesity and metabolic syndrome.
    > In studies on rats with metaphit-induced epilepsy DSIP acted as an anticonvulsant, significantly decreasing the incidence and duration of fits suggesting DSIP as a potential treatment for epilepsy.
    > DSIP has been found to have an analgesic effect. In studies on mice it was found to have a potent antinociceptive effect when administered intracerebroventricularly or intracisternally (see: Route of administration).
    > Due to its possible effects on sleep and nociception, trials have been carried out to determine whether DSIP can be used as an anaesthetic. One such study found that administration of DSIP to humans as an adjunct to isoflurane anaesthesia actually increased the heart rate and reduced the depth of anaesthesia instead of deepening it as expected.
    > Low plasma concentrations of DSIP have been found in patients with Cushing's syndrome.
    > In Alzheimer's patients levels of DSIP have been found to be slightly elevated, though this is unlikely to be causal.
    > A preparation of DSIP, Deltaran, has been used to correct central nervous system function in children after antiblastomic therapy. Ten children aged 3–16 years were given a ten-day course of Deltaran and their bioelectric activity recorded. It was found that the chemotherapy-induced impairment in the bioelectrical activity of 9 out of the 10 children was reduced by administration of DSIP.
    > DSIP can act antagonistically on opiate receptors to significantly inhibit the development of opioid and alcohol dependence and is currently being used in clinical trials to treat withdrawal syndrome. In one such trial it was reported that in 97% of opiate-dependent and 87% of alcohol-dependent patients the symptoms were alleviated by DSIP administration.
    > In some studies administration of DSIP has alleviated narcolepsy and normalized disturbed sleeping patterns.
  • Buy DSIP (Delta Sleep-Inducing Peptide) from Biopro for discount on the first order.
  • Reference List of Available Peptides
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    CJC-1295 DAC2 mgTriptorein2 mg
    CJC-1295 no DAC2 mgMelanotan I10 mg
    Epithalon10 mgMelanotan II10 mg
    FST-3441 mgPT-14110 mg
    Fragment 176-1915 mgMGF2 mg
    GHRP-25 mgPEG-MGF2 mg
    GHRP-65 mgSelank5 mg
    Gonadorelin10 mgDSIP2 mg
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    Ipamorelin2 mgIGF-1 (1-3)1 mg
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Peptide Growth Hormone

      
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